HDAC4 is essential for memory in Drosophila and mammals. The current issue of Genetics features our paper showing that HDAC4 interacts with Ubc9, the sole SUMO E2-conjugating enzyme, during memory formation (web). This study should open new avenues for research on how long term memories are established. The study was led by Helen Fitzsimons, a former postdoc in the lab, and follows on previous work on HDAC4 and HDAC1 and long term memory in Drosophila.
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